Ultimo aggiornamento 2020-11-19    9:00:30 PM

Feedback indica il processo per cui un’azione o una sostanza prodotta da un organo si riflette sull’organo stesso che l’ha prodotto  per correggerne o modificarne il comportamento in modo tale da creare e mantenere l’omeostasi dell’organismo.

Le strutture in cui si osservano classicamente i fenomeni di feed-back sono quelle dell’asse ipotalamo-ipofisi-organi periferici.

Il feed-back di solito é di tipo inibitorio o negativo.

Nel caso specifico dell’asse ipotalamo-ipofisi-ovaio, quanto più aumenta la produzione di estrogeni a livello dell’ovaio tanto più i livelli ematici di questi steroidi frenano la produzione ipotalalmica di Gn-RH e quella ipofisaria di LH e FSH (feed-back lungo negativo).

Quanto più a causa della stimolazione del Gn-RH ipotalamico aumentano i livelli ematici di FSH ed LH ipofisari, tanto più aumenta l’azione di freno da parte di queste gonadotropine sulla produzione di Gn-RH (feed-back negativo corto)  e sulla stessa ipofisi (feed-back ultracorto). 

Altro classico esempio di feed-back negativo e positivo si riscontra nel metabolismo dell’asse GH-IGF I-II.



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