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Farmaci in Gravidanza e Allattamento

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FARMACI ANTIMIASTENICI

Tiacrina: produce effetti colinergici (o parasimpaticomimetici) nel feto stimolando sia i recettori nicotinici (interessati nel metabolismo degli ioni sodio, potassio e cloro e stimolati dalla nicotina e inibiti dal curare), sia i recettori muscarinici stimolati dalla muscarina ed inibiti dall’atropina. Gli effetti colinergici comprendono:

  • vasodilatazione generale, diminuzione della gittata e dell’inotropismo cardiaco,
  • contrazione della muscolatura liscia intestinale, bronchiale e vescicale,
  • aumento della secrezione delle ghiandole sudoripare, lacrimali e bronchiale,
  • attivazione dei recettori M1 con aumento della capacità cognitive e locomotoria, ipotermia e tremori

Tab. 15 bis farmaci antiastenici

management

Tacrina

Tacrine C

C

Produce effetti colinergici
(parasimpaticomimetici) nel feto

 

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