Farmaci in Gravidanza e Allattamento

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Farmaci per uso topico: Non esistono dati su controindicazione in gravidanza ma neanche studi che ne confermino l’assoluta innocuità.

  • Imiquimod: Aldara™ 5% crema in bustine: utilizzata nella terapia dei condilomi acuminati (papilloma virus) in associazione a rimozione chirurgica con lasera, diatermocoagulazione, causticazione con ac. tricloroacetico. Appartiene alla classe degli «Immune Response Modifier», modulatori della risposta immunitaria cioè stimolano la risposta immunitaria locale. Non vi sono dati disponibilisull`uso di imiquimod crema derivante la gravidanza o sui suoi effetti durante l`allattamento. Si raccomanda quindi l`uso esclusivamente nei casi in cui i benefici sono decisamente superiori al rischio.
  • Ac. Fusidico: molto attivo contro alcuni patogeni caratteristici della cute quali lo Staphylococcus aureus, il Propionibacterium acnes ed il Corynebacterium. L’acido fusidico esercita la sua attività antibatterica per inibizione della sintesi proteica nei batteri. Dopo 30 anni di uso in terapia la resistenza al Fucidin è risultata rara (1 – 2%). I batteri resistenti alle Penicilline sono molto spesso sensibili all’acido fusidico. La somministrazione di crème contenenti ac. Fusidico dovrebbe essere evitata negli ultimi giorni di gravidanza, potrebbe procurare kernicterus (bilirubinemia >0.2 mg/ml) nel neonato per competizione recettoriale con la bilirubina per il legame con l’albumina.

Tab. 39 – farmaci per uso topico



Chemicetina ovuli

Ctg B2


Cleocin ovuli

Ctg B2

Tirotricina + nitrofurazone

Furotricina ovuli

Ctg B3

Tirotricina + betametasone

Deltavagin ovuli

Ctg B3

Ac. fusididico

Dermomycin, Dermomycin cort, Fucidin creme

Ctg C

Da non utilizzare negli ultimi giorni di gravidanza per
rischio di kernicterus



Ctg B3


Ecomi, Ganazolo, Ifenec, Pevaryl, Polinazolo

Ctg B3


Travogen, Abimono

Ctg B3


Daktarin, Micotef

Ctg B3



Ctg B3

Nifuratel + Nistatina

Macmiror Complex ovuli

Ctg B3


Neoxene cps vag.,
gel vag., lavanda vag.

Ctg B3

Ac. borico

AB 300 Flac P, Abimono ovuli, AB 300 ovuli

Ctg B3

Ac. borico + alfa

Ac. borico + clorexidina

Micoschiuma soluz. Gin.

Ctg B3

Crotamitone + sucralfato + ac. borico

Mitolene latte spray uso esterno

Ctg A2

Ac. ialuronico + Ac. glicirretico + Vit A +

Finderm forte ovuli

Ctg A

Lattobacilli + ac. lattico + isoflavoni
di soia

Triacid cpr vaginali

Ctg B3

Rischio di femminilizzazione dei feti di
sesso maschile

Lattobacilli + Policarbophil (resina idrofila)

Lactofil cps vag., lactofil forte cps vag.

Ctg A

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