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- i glicosidi digitalici: attraversano la placenta, ma i neonati (e i bambini) sono relativamente resistenti alla loro tossicità. Solo l’1% di una dose di digitossina iniettata alla madre, compare nel feto sotto forma di digitossina immodificata e il 3% compare sotto forma dei suoi metaboliti, ma si possono osservare delle concentrazioni maggiori di digitossina, soprattutto durante il primo trimestre. I neonati di madri che fanno uso di digitossina, presentano una concentrazione plasmatica paragonabile a quella della madre, senza segni di effetti dannosi.
- Amiodarone: può indurre ipotiroidismo e soprattutto ipertiroidismo nella gravida, mentre nel feto induce ipo/ipertiroidismo, gozzo congenito e bradicardia. E’ secreto in quantità significative nel latte materno. E perciò da utilizzare in gravidanza e allattamento solo in caso di effettiva necessità.
tab. 34 – Farmaci cardiaci
ctg B2; Assenza di tossicità fetale o malformzaioni
Classe D della FDA
Ctg B2 della FDA
ctg B2; Assenza di tossicità fetale o
utilizzato per le aritmie fetali
ctg B2; Assenza di tossicità fetale o
ctg C della FDA
Controindicati in presenza di contrazioni
ipossia fetale, bradicardia, ipoglicemia,
Ignoti gli effetti sul feto
ctg B2; Ignoti gli effetti sul feto
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