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Il betanecolo è un estere sintetico della colina, quindi un farmaco parasimpaticomimetico diretto. Differisce strutturalmente dall’acetilcolina (ACh) per la presenza di un gruppo amminico (-NH2) oltre ad avere un gruppo metilico sul carbonio a. Utilizzato per la terapia dell’atonia gastrica, ritenzione urinaria e distensione addominale post-operatoria. Agisce legandosi ai recettori colinergici muscarinici e quindi produce reazioni tipiche del sistema parasimpatico:
Apparato cardiovascolare: vasodilatazione, ipotensione, effetti cronotropo, inotropo e dromotropo negativi.
Apparato gastrointestinale: aumento del tono della muscolatura liscia, ampiezza e contrazioni più aumento dell’attività secretoria di stomaco e intestino.
Apparato respiratorio: broncocostrizione e stimolazione dei chemocettori dei glomi aortico e carotideo.
Apparato urinario: contrazioni del muscolo detrusore della vescica.
Ghiandole esocrine: aumento dell’attività delle ghiandole esocrine stimolate dal parasimpatico.
Apparato riproduttivo maschile: erezione.
Sistema nervoso centrale: nessuna attività in quanto non attraversa la barriera emato-encefalica perché ha un azoto quaternario.
Contrindicato in gravidanza per possibile insorgenza di contrazioni uterine,
Tab. 20 ter – Altri Ormoni
Non ci sono dati
ctg X della FDA
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