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Tiacrina: produce effetti colinergici (o parasimpaticomimetici) nel feto stimolando sia i recettori nicotinici (interessati nel metabolismo degli ioni sodio, potassio e cloro e stimolati dalla nicotina e inibiti dal curare), sia i recettori muscarinici stimolati dalla muscarina ed inibiti dall’atropina. Gli effetti colinergici comprendono:
- vasodilatazione generale, diminuzione della gittata e dell’inotropismo cardiaco,
- contrazione della muscolatura liscia intestinale, bronchiale e vescicale,
- aumento della secrezione delle ghiandole sudoripare, lacrimali e bronchiale,
- attivazione dei recettori M1 con aumento della capacità cognitive e locomotoria, ipotermia e tremori
Tab. 15 bis farmaci antiastenici
Produce effetti colinergici
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